In the submandibular salivary gland and the lymph node of Mikulicz's disease patients, Nanke et al. detected IFN-γ+, IFN-γ+IL-17+, and IL-17+ cells, which are proposed to be Th17/Th1 cells, suggesting that Th17/Th1 cells may be involved in the pathogenesis of Mikulicz's disease [133]. The gene discussed is IFNG; the disease is IgG4-related dacryoadenitis and sialadenitis.