Furthermore, VEGF is considered a key factor in tumor-induced immunosuppression.22, 23, 24 Nevertheless, in the result of our study, adding BEV did not translate into an advantage, which indicates that the addition of BEV may not be associated with improvement of durable antitumor response for non-Sq tumors with MPE treated with ICI/Chemo. The gene discussed is VEGFA; the disease is neoplasm.