TNF and obesity due to melanocortin 4 receptor deficiency: - Anti-obesity, anti-hyperlipidemia, anti-hyperglycemia, anti-inflammation and anti-oxidation (↓body weight, ↓serum TG, TC, HDL-C, LDL-C, glucose, TNFa, MCP-1; ↑serum adiponectin; ↑liver GSH, SOD, CAT, T-AOC, GSH-Px; ↓liver MDA) in HFD-mice (10 mg/kg bw, p.o., 8 weeks).