PPARG and obesity due to melanocortin 4 receptor deficiency: - Anti-obesity, insulin sensitizer (↓body weight; ↓eWAT; ↓adipocyte size; ↓serum triglyceride; ↓serum insulin; ↓glucose; ↓HOMA-IR) (0.01%, 0.025% of diet, 8 weeks). - Anti adipogenesis in 3T3-L1 cells (↓C/EBPα, PPARγ, FASN, Ap2) (5, 10 μM for 48 h).