GPT and obesity due to melanocortin 4 receptor deficiency: - Anti-obesity, anti-hepatic steatosis, insulin sensitizer (↓body weight; ↓fat mass;↑energy expenditure; ↓liver weight, TG, FFA, AST, ALT; ↓serum glucose in GTT and ITT; ↓HOMA-IR index) in HFD-fed wild-type mice but not in HFD-fed Nrf2 knockout mice (0.3% of diet, 14 weeks).