- Anti-obesity [↓body weight (10 g/kg bw)] and promoted methylation of CpG island in the FTO promoter in HFD-mice (2, 5, 10 g/kg bw, p.o., 4 weeks). - FTO expression in high dose group (10 g/kg bw) were significantly higher than control. This evidence concerns the gene FTO and obesity due to melanocortin 4 receptor deficiency.