Picrasidine C, a dimeric β-carboline-type alkaloid isolated from the root of Picrasma quassioides, was identified as a selective PPARα agonist by binding with PPARα LBD forming hydrogen bonds with Cys276 and Thr279, therefore exhibiting potential in treating hyperlipidemia, atherosclerosis, and hypercholesterolemia (80). This evidence concerns the gene PPARA and Hypercholesterolemia.