UCP1 and obesity due to melanocortin 4 receptor deficiency: - Anti-obesity (↓body weight, eWAT, iWAT; ↓serum ALT, glucose, FFA, LDL-C; ↑energy expenditure) in HFD-mice (100, 200 mg/kg bw, p.o., 12 weeks). - Stimulated expression of UCP1 in wild-type adipocyte but not in Nrf2 knockout cells.