Tang and colleagues found that obesity, glycolipid metabolism disorder, inflammation, and oxidative stress were effectively alleviated by kaempferide treatment for 16 weeks in HFD mice, and the beneficial effects of kaempferide may be associated with inhibition of the TLR4/IκBα/NF-κB signaling pathways (30). The gene discussed is TLR4; the disease is obesity due to melanocortin 4 receptor deficiency.