TLR4 and obesity due to melanocortin 4 receptor deficiency: Mohamad reported that administrate with withaferin A (1.25 mg/kg/d) for 12 weeks protected against high-fat diet induced obesity through reducing hepatic mRNA expressions of TLR4, NF-κB, TNF-α), chemokine (C-C motif) ligand-receptor, and cyclooxygenase 2 (COX2) (29).