LEP and steatosis: - Anti-hyperglycemia and insulin sensitizer (↓body weight; ↓blood glucose; ↓HOMA-IR, ↓blood glucose and insulin in GTT; ↑pancreatic insulin; ↓plasma ALT,TG, FFA) in HFD-obese mice, and ↓ plasma insulin; ↓plasma TG; ↑pancreatic insulin in db/db mice (100 mg/ kg bw, p.o., 3 weeks). - Anti-steatosis (↓body weight; ↓plasma insulin, leptin; ↓liver TG) in HFD-obese mice (37 mg/ kg bw, p.o., 15 weeks).