PPARA and familial hypercholesterolemia: Picrasidine C, a dimeric β-carboline-type alkaloid isolated from the root of Picrasma quassioides, was identified as a selective PPARα agonist by binding with PPARα LBD forming hydrogen bonds with Cys276 and Thr279, therefore exhibiting potential in treating hyperlipidemia, atherosclerosis, and hypercholesterolemia (80).