Consistently, the mRNA levels of inflammatory mediators TNF-α and IL-1β, as well as IL-6, ICAM, CCL2, CXCL2, and TGF-β, which were indicated as progressive inflammatory response and liver fibrosis, were significantly elevated in the liver of MFG-E8 knockout mice compared with the MCD-WT group (Figure 6(c)). Here, TGFB1 is linked to Hepatic fibrosis.