In comparison with the XLH group, the TIR/O group showed a much higher serum level of FGF23 (521.08 ± 101.24 versus 105.61 ± 45.38 pg/ml, p = 0.003), a significantly lower serum level of phosphate (0.50 ± 0.08 versus 0.76 ± 0.22 mmol/L, p = 0.019), and a markedly evaluated serum level of ALP (991 ± 516 versus 351 ± 221 U/L, p = 0.048), whereas the serum β-CTX levels were not significantly different. This evidence concerns the gene FGF23 and X-linked hypophosphatemia.