As this factor also takes part in many processes, such as angiogenesis, embryogenesis, wound healing, inflammation, tumor metastasis, cardiovascular diseases, or rheumatoid arthritis (21), and its concentration can be influenced by significant familial correlations of its plasma concentration between genetically related individuals (54), it is difficult to confidently point out the reason for the difference between its concentration in girls during GH therapy. Here, GH1 is linked to rheumatoid arthritis.