ROCK2 and renal fibrosis: ROCK2, instead, was found to be a target of miR-455-3p which was down-regulated in the human mesangial cells and human proximal tubule epithelial cells when stimulating with high glucose or transforming growth factor beta 1 (TGF-β1); restoring miR-455-3p expression in a rat diabetic nephropathy model decreased ROCK2 expression and suppressed renal fibrosis (83).