Together, besides the well-established role for the RhoA/ROCK/F-actin/MRTF-A/SRF pathway in regulating vascular cell function, abovementioned studies support that the RhoA/ROCK/F-actin/MRTF-A/SRF pathway negatively regulates adipocyte differentiation, plays a negative role in maintaining adipose tissue health, and contributes to liver fibrosis and diabetic nephropathy. This evidence concerns the gene RHOA and diabetic kidney disease.