CCN2 and diabetic kidney disease: In addition to adipose tissue, MRTF-A/SRF pathway is involved in hepatic fibrosis (119) and diabetic nephropathy (120): MRTF-A knockout reduced macrophage infiltration, and ameliorated inflammation and fibrosis of liver tissues in mice with nonalcoholic steatohepatitis induced by high-fat diet (HFD) (119); through an epigenetic mechanism, MRTF-A deficiency also attenuated connective tissue growth factor in diabetic nephropathy (120).