INS and hyperandrogenism: Compared with the control group, PCOS subjects also had higher levels of fasting insulin, HOMA-IR, HOMA-β, CHOL, TGs, HDL, and LDL but lower levels of fasting glucose and QUICK I. These results suggested that PCOS is a heterogeneous disorder with multiple phenotypes, but the core pathogenesis of PCOS was IR and hyperandrogenism (HA).