In the first genome-wide single SNP-based and gene-based analysis on prediabetes status change conducted in participants of European ancestry, we identified 5 novel genes, SGCZ at 8p22, HPSE2 at 10q24.2, ADGRA1 at 10q26.3, GLB1L3 at 11q25, and PCSK6 at 15q26.3 that were associated with prediabetes status change. The gene discussed is GLB1L3; the disease is prediabetes syndrome.