Several of the previous biomarkers for predicting the individual treatment response to antipsychotics were based on the molecular pathological mechanism of SZ and the biochemical pathway,10, 11, 12 such as brain‐derived neurotrophic factor (BDNF), 5‐hydroxytryptamine receptor 2C (HTR2C), serotonin (5‐HT2A (5‐HT2A), leptin, and fat mass and obesity‐associated gene (FTO).13, 14, 15, 16. This evidence concerns the gene BDNF and obesity due to melanocortin 4 receptor deficiency.