GRHL2 and neoplasm: We recapitulated positive associations in paralog buffering (e.g., SMARCA4_LOF/SMARCA2ess, Fig. 1E), oncogenic mutation-induced essentiality (e.g., BRAF_GOF/BRAFess, Fig. 1F), and tumor-specific dependencies (e.g., CML/BCRess, Fig. 1G), as well as negative associations such as epithelial transcription factor GRHL2 essentiality in cells with low CDH1/VIM expression ratio (Fig. 1H) and increased essentiality of cyclin D1 (CCND1) in cells with wildtype RB1 (Fig. 1I).