Moreover, we show that SYT11 plays an important role in GC cell proliferation and metastasis by functioning as scaffold to organize the JNK-MKK7 interactions thereby JNK phosphorylation regulation and EMT-related gene expression, and suggest that SYT11 is a novel prognostic biomarker and therapeutic target against stem-like molecular subtype diffuse GC. Here, MAP2K7 is linked to gastric cancer.