Previous studies on GC genomic analysis by The Cancer Genome Atlas (TCGA) Research Network [1] and the Asian Cancer Research Group (ACRG) [2] have identified four distinct molecular subtypes linked to unique somatic alteration and clinical phenotype patterns: Epstein–Barr virus (EBV), microsatellite instability (MSI), chromosomal instability (CIN) and genomically stable (GS) subtypes by TCGA, and microsatellite instability (MSI), microsatellite stable with epithelial-mesenchymal transition (MSS/EMT), MSS/TP53+, and MSS/TP53- by ACRG [2]. The gene discussed is TP53; the disease is cancer.