Thyroid Hormones may affect sex hormone metabolism and synthesis, including but not limited to testosterone metabolism, secretion of gonadotropin-releasing hormone (GnRH), and the responses of LH and follicle-stimulating hormone (FSH) to GnRH administration, thus influencing the androgen function with ultimate consequences for AGD [35, 36]. The gene discussed is GNRH1; the disease is argyrophilic grain disease.