KEGG-based analysis showed that overexpressed genes mainly involved the p53 signaling pathway, ferroptosis, Kaposi sarcoma-associated herpesvirus infection, IL-17 signaling pathway, MicroRNAs in cancer, the TNF signaling pathway, PI3K-Akt signaling pathway, and HIF-1 signaling pathway (Fig. 1A-D). The gene discussed is SETD2; the disease is cancer.