By studying the protein-protein interaction network, CHEK2 (checkpoint kinase 2), OCIAD2 (OCIA domain containing 2), UBE2L3 (ubiquitin-conjugating enzyme E2 L3), and ZNF367 (zinc finger protein 367) were predicted to be the transcriptional targets of PTTG1 in BLCA (Fig. 9A). This evidence concerns the gene CHEK2 and bladder transitional cell carcinoma.