By studying the protein-protein interaction network, CHEK2 (checkpoint kinase 2), OCIAD2 (OCIA domain containing 2), UBE2L3 (ubiquitin-conjugating enzyme E2 L3), and ZNF367 (zinc finger protein 367) were predicted to be the transcriptional targets of PTTG1 in BLCA (Fig. 9A). The gene discussed is UBE2L3; the disease is bladder transitional cell carcinoma.