RPL17 and cancer: For the blue gene module, the top 100 hub genes were enriched in several KEGG pathway (Fig. 6A), such as, Natural killer cell mediated cytotoxicity, Th17 cell differentiation, Neutrophil extracellular trap formation, PD − L1 expression and PD − 1 checkpoint pathway in cancer, and Leukocyte trans-endothelial migration pathways.