Ccl17 and Cxcr3 increased in mammary tumors that protects cancer cell survival and induce tumor growth to promote breast cancer lung metastasis [28, 29] Hypoxia-induced chemokine Sema3a stimulates tumor-associated macrophages to the alternative type (M2), leading to pro-tumor immunity [30]. The gene discussed is SEMA3A; the disease is breast carcinoma.