AKT1 and osteogenesis imperfecta: To further explore the relationship between OI, the PI3K/AKT/mTOR signalling pathway and autophagy, we treated C28/I2 cells with chloroquine (CQ) (a specific inhibitor of autophagy) and compared the differences among the control, IL-1β, IL-1β + OI, CQ and CQ + OI groups.