PDE3A and cancer: In in vitro experiments, SLFN12 cleaves rRNA as an active RNase complex with phosphodiesterase 3A (PDE3A), enhancing DNMDP (6-(4-(diethylamino)-3-nitrophenyl)-5-methyl-4,5-dihydropyridazin-3(2H)-one)-induced cancer cell death14.