DCIS proximity index for lymphocytes, CD3+ T-cells, CD20+ B-cells, CD3+CD8− T-cells, CD3+FOXP3+ T-cells, CD3+CD8+ T-cells and CD68+ cells per DCIS cell did not differ between cases and controls (Supplementary Fig. 2, P > 0.05). This evidence concerns the gene CD8A and ductal breast carcinoma in situ.