In particular, we find that density, composition and distance to the closest DCIS cell of lymphocytes, CD3+ T-cells, CD20+ B-cells, CD3+CD8− T-cells, CD3+CD8+ T-cells, CD3+FOXP3+ T-cells, CD8+Ki67+ activated T-cells and CD68+ macrophages do not differ between DCIS patients that developed subsequent iIBC versus DCIS patients that did not. Here, CD8A is linked to ductal breast carcinoma in situ.