NSUN3 and cancer: Consequently, maximal cellular respiration was reduced when mt-tRNAMet was hypomodified (Fig. 2d,e and Extended Data Fig. 2j,k), and the basal extracellular acidification rate (ECAR) was higher overall in NSUN3-deficient cancer cells (Fig. 2f and Extended Data Fig. 2g–i,l–o).