One interesting candidate for additional study would be tumour necrosis factor-alpha biology given elevated TNFRSF1A has also been associated with schizophrenia, bipolar disorder, and autism in the large post-mortem brain expression study from the PsychENCODE consortium64, although genetic evidence from GWAS for this gene is still lacking in the context of psychiatric phenotypes. The gene discussed is TNFRSF1A; the disease is bipolar disorder.