Unlike other BrafV600E-driven mouse melanoma models (e.g., BrafV600E/Cdkn2a−/−, BrafV600E/Trp53−/−), which still mainly induce nevus formation, we were unable to appreciate any obvious nevogenesis in BrafV600E/Lats1/2−/− mice. This evidence concerns the gene LATS1 and nevus.