Frequent focal losses tended to center at or near known tumor suppressors in MM, such as GFI1, FAM46C, CDKN2C, ARID1B, NKX3-1, CDKN2A/B, BIRC2/3, CDKN1B, RB1, TRAF3, and CYLD, while focal gains were at or near oncogenes including MYC, CCND1, and TXNDC5 (Fig. 1b)13. This evidence concerns the gene NKX3-1 and Miyoshi myopathy.