At the same time PIK3CA and TP53 variant spectra in the normal glandular tissue were more similar to the ones reported in cancer-oriented database (COSMIC) than those in general population (gnomAD), suggesting that the studied UM tissues reflect the repertoire of somatic variants seen in tumor samples (Supplementary Fig. 9, Supplementary Fig. 10, Supplementary Table 9). Here, PIK3CA is linked to cancer.