The changes observed in the relative proportion of cells belonging to the other clusters indicate that during the anti-tumor response, Suv39h1 represses IFN-I signaling, and part of the exhaustion program, restraining the cells in a more memory/progenitor exhausted state, and T cell reinvigoration induced by PD-1 blockade drives these cells into a terminally exhausted program. Here, SUV39H1 is linked to neoplasm.