CD4 and neoplasm: Along these lines, the percentages of tumor-infiltrating myeloid cells (CD11b+ cells, cDC1, and cDC2 cells), CD4+ T cells, and NK and were similar in untreated WT and Suv39h1-KO animals, and were not significantly modified by the anti-PD-1 treatment (Supplementary Fig. 2A); while the percentage and absolute number of CD8+ TILs were increased in the Suv39h1-KO mice as compared to WT littermates, and were expanded further after treatment with anti-PD-1 Ab (Fig. 1E).