CX3CL1 stimulates the chemotactic migration and cytotoxicity of CX3CR1+ NK cells through the STAT3 signaling pathway to control the occurrence and metastasis of HCC.177 It is feasible to regulate the migration of NK cells to intratumoral tissues in HCC by targeting CXCR3-CXCL10 and CX3CL1-CX3CR1 through drug stimulation or genetic engineering. The gene discussed is STAT3; the disease is hepatocellular carcinoma.