Melanoma cells also express CCR7 and concurrently express PD-L1 and Gal-9, especially when they are metastatic.185 In light of the finding that trogocytosis of tumor cell-derived CCR7 to NK cells results in NK cell trafficking from tumor tissue to LNs,134 blockage of the CCR7-CCL19 axis may keep more NK cells in the TME. This evidence concerns the gene CD274 and neoplasm.