Expression of the CXCR3 receptor in human NK cells expanded in vitro with a high dose of IL-2 (1000 IU/ml) was 10 times greater than in resting NK cells, and the expanded cells showed increased migration toward melanoma cells in a CXCL10-dependent manner.184 This suggests that strategies for improving CXCR3 expression on NK cells that have been expanded ex vivo may become potential weapons against melanoma. The gene discussed is CXCR3; the disease is melanoma.