NK cells with a migration phenotype are found in RCC tumor tissues compared with healthy kidney tissues.217 Increased expression of chemokine-receptor (CXCL9-11/CXCR3) is also detected in RCC.218 When NK cells are genetically modified to overexpress CXCR2, their migration and ability to resist RCC cells are enhanced in vitro.219. This evidence concerns the gene CXCR2 and neoplasm.