Expression of the CXCR3 receptor in human NK cells expanded in vitro with a high dose of IL-2 (1000 IU/ml) was 10 times greater than in resting NK cells, and the expanded cells showed increased migration toward melanoma cells in a CXCL10-dependent manner.184 This suggests that strategies for improving CXCR3 expression on NK cells that have been expanded ex vivo may become potential weapons against melanoma. This evidence concerns the gene CXCL10 and melanoma.