CXCR2 and renal cell carcinoma: NK cells with a migration phenotype are found in RCC tumor tissues compared with healthy kidney tissues.217 Increased expression of chemokine-receptor (CXCL9-11/CXCR3) is also detected in RCC.218 When NK cells are genetically modified to overexpress CXCR2, their migration and ability to resist RCC cells are enhanced in vitro.219