This observation confirms the role of CXCR3+ NK cells in HCC.175 Enhancer of zeste homolog 2 (EZH2) is a histone H3 lysine 27 methyltransferase, which impedes the migration of NK cells by inhibiting the transcription of CXCL10 in tumor cells.176 MiR-561-5p controls the infiltration and functions of CX3CR1+ NK cells through CX3CL1-dependent regulation. This evidence concerns the gene CX3CR1 and hepatocellular carcinoma.