Diethylnitrosamine-treated wild-type mice that had received BM from CXCR6-deficient mice developed more liver tumors and fewer invariant NKTs.178 Given that CXCR6 is critical for the homing of both NK cells and T cells to the liver, targeting CXCR6 could be an alternative way to improve the efficiency of HCC immunotherapy. This evidence concerns the gene CXCR6 and hepatocellular carcinoma.