KRAS and lung cancer: So not surprisingly, lung cancer is the leading cause of cancer death among both men and women in the U.S.208 NK cells are located mainly in the parenchyma of the lungs, accounting for 10% to 20% of lymphocytes.209 In a mouse model of Kras-driven lung cancer, the number of NK cells gradually decreased between tumor initiation and tumor progression.210 Also, a transcriptional assay uncovered significant changes in migratory patterns of tumor-infiltrated NK cells in the TME of human NSCLC.