Although IKZF3 deletion impaired NK cell terminal maturation and did not affect the cytotoxic function of freshly isolated NK cells in vitro, it enhanced in vivo anti-tumor activity in a mouse lung melanoma metastasis model and tended to increase the ratio of NK cells to tumor cells in the TME.238 RNA-seq analysis showed that IKZF3-deficient mice had significantly higher mRNA levels of CXCR2 than wild-type NK cells. The gene discussed is CXCR2; the disease is neoplasm.