In several preclinical studies, co-expression of a CAR and a chemokine receptor on T cells increased the cells’ invasion into tumors and also boosted their effectiveness against solid tumors.288 CAR T cells equipped with CXCR2,289 CCR2b,290 or CXCR5291 increased their chemotaxis to tumor cells, where the anti-tumor effects of T cells are enhanced. Here, CXCR2 is linked to neoplasm.