In contrast, CAR NK cells launch anti-tumor activity via direct cytotoxicity, as they release neoantigens after lysing target cells, and the abundant cytokines they produce, especially IFN-γ, do not trigger cytokine release syndrome.278 IFN-γ, a strong immune enhancer, plays multifaceted roles in remodeling the TME. The gene discussed is IFNG; the disease is neoplasm.