RARRES2 and autoimmune disease: The chemotactic activity of the chemerin-ChemR23 axis was first reported to mediate the migration of plasmacytoid DCs and NK cells involved in autoimmune diseases.191,192 Further study revealed that chemerin was downregulated during melanoma growth and that it suppresses melanoma growth by recruiting NK cells in a ChemR23-dependent manner.193 Recent studies revealed that all-trans retinoic acid, a potent inducer of chemerin, enhances the recruitment of ChemR23-dependent NK cells and suppresses melanoma growth.194