The degree to which tumor-infiltrating CD49a+ NK cells accumulate in the liver strongly affects prognosis for patients with HCC.179 A comparison of CD49a+ and CD49a− NK cell transcripts showed that CD49a+ NK cells highly express CXCR6 and CCR3.179 However, previously defined liver CD49a+ NK cells are now considered to be liver-resident ILC1s that differentiate from liver-resident Lin−Sca-1+Mac-1+ progenitor cells.36 The presumed link between the accumulation of CD49a+ NK cells (or ILC1s) and prognosis in HCC needs to be reevaluated. The gene discussed is CXCR6; the disease is hepatocellular carcinoma.