In our genome-wide siRNA knock-down of host proteins to identify binding sites for B. bifidum the best four hits were structural proteins, but our screen revealed decreased adhesion also when glycosylating enzymes glycosyltransferase 1 domain (GLT1D1, 34%) or glucosidase, alpha; acid (Pompe disease, glycogen storage disease type II) (9,5%) were knocked down (Fig. 3, Supplementary Fig. 2, Supplementary Table 1). The gene discussed is GAA; the disease is Glycogen storage disease due to acid maltase deficiency.