The discovery that DHX34 is involved in the regulation of pre-mRNA splicing is suggestive in regards to its function in AML/MDS, since recurrent mutations are found in myeloid malignancies including genes encoding splicing factors, LUC7L2, RBM39, SF3B1, SRSF2, and U2AF1 (Zhang et al. 2015; Inoue et al. 2016; Lee et al. 2016; Wang et al. 2019; Rahman et al. 2020; Daniels et al. 2021). The gene discussed is U2AF1; the disease is acute myeloid leukemia.