Interestingly, the DHX34 pre-mRNA is subject to widespread alternative splicing in sporadic AML, which results in the inclusion of a poison exon harboring a PTC, leading to a decrease in DHX34 mRNA levels due to alternative splicing coupled to NMD (AS-NMD) (Rivera et al. 2021). This evidence concerns the gene DHX34 and acute myeloid leukemia.