PTCH1 and ovarian neoplasm: In the Manchester cohort, systematic ultrasound in individuals with GS led to the detection of an ovarian tumour in 3/7 females (43%) with germline SUFU PV, compared with 4/68 females (5.9%) with PTCH1 PV.19 In the present series, the cumulative incidence of ovarian tumours has been estimated at around 10% at 50 years in females (4.6% in the entire population).