PTCH1 and skin basal cell carcinoma: Nevertheless, meningioma seems to be more frequent in SUFU PV carriers (11%) than in the Manchester cohort of 126 patients with GS associated with PTCH1 germline PVs in whom the incidence of meningiomas was <2%.19 In contrast, the risk of BCC for SUFU PV carriers is clearly lower than for those with a PTCH1 PV with only 11/31 (35%) SUFU patients >50 years affected with BCC.