On the contrary, a diet richer in fat energy (usually60%) and cholesterol, as well as long-term treatment, is more appropriateto study the final stages of atheroma plaque generation (commonlycalled late atherosclerosis).39 This ispossible due to ApoE–/– mice have been shownto develop the entire spectrum of all steps of atherosclerosis, includingthe early stages depending on the type of diet and the duration ofthe consumption.7,31,32,40. This evidence concerns the gene APOE and atherosclerosis.