APOE and atherosclerosis: In conclusion, althoughprevious studies have shown that LPI candecrease the calcification of atherosclerotic lesions in ApoE knockoutmice,14,58 the present study shows the multifunctionalproperties of the peptides from lupin in the key steps of atherosclerosis.LPH, produced by hydrolysis with Alcalase, contained peptides withseveral motifs associated with hypolipidemic, antioxidant, immunomodulating,and antithrombotic effects.