WT mice developed autoimmune colitis within 3 to 4 days following DSS administration and showed visible signs of illness including hunched back, raised fur, symptoms of sepsis, and reduced mobility because of diarrhea and anemia; notably, the occurrence of colitis declined remarkably in NAC1−/− mice (Fig. 4, D to H). The gene discussed is NACC1; the disease is anemia (phenotype).