In addition, the genes LY96 (Tissières et al. 2009), ZBTB16 (Girard et al. 2013; Quaranta et al. 2006) and PIK3CD (Kok et al. 2009) which are related to myeloid cells were found to be key genes involved in IDD. The gene discussed is ZBTB16; the disease is intervertebral disk degenerative disorder.