The top enriched MF terms for orangered4 module suggested that the ability of interacting selectively and non-covalently with an organic acid or carboxylic acid or beta-catenin might be hampered in IDD patients, among which beta-catenin was proposed as a mediator of immune evasion which are exploited by cancer cells to hide from host immune responses (Du et al. 2020; Sorci et al. 2013). The gene discussed is CTNNB1; the disease is intervertebral disk degenerative disorder.