After the selection by LASSO algorithm, we obtained 8 pivotal IDD markers (ANXA3 and ZBTB16 (down-regulated in IDD patients), MSH2 and LY96 (up-regulated in IDD patients with p value less than 0.01), along with ADAM8, HEBP2, RAB24, PIK3CD (up-regulated in IDD patients)) and evaluated their expression in validation set. The gene discussed is MSH2; the disease is intervertebral disk degenerative disorder.