Histone deacetylation is a pleiotropic immune regulator that not only participates in the development and differentiation of myeloid, but also regulates the functions of the mature leukocytes (such as macrophage and dendritic cells) through controlling the generation of inflammatory factors (Shakespear et al. 2011), while interleukin-8 is a pro-inflammatory chemokine generated by macrophages (Hedges et al. 2000); thus, the enrichment results showed that orangered4 module genes might counteract the IDD through regulating immune processes induced by histone deacetylation and interleukin-8. This evidence concerns the gene CXCL8 and intervertebral disk degenerative disorder.