Protein kinase B is a well-established serine/threonine kinase whose activation depend greatly on its phosphorylation during the immune activation of T cells (Fabre et al. 2005; Finlay and Cantrell 2011); these might explain the involvement of magenta module genes in “protein serine/threonine kinase activity”, since activated leukocytes might be accompanied by elevated protein serine/threonine kinase activity in IDD patients. Here, MARK2 is linked to intervertebral disk degenerative disorder.