have an anti-adiposity effect, ameliorate obesity in HFD-induced obesity model and can alleviate obesity by regulating gut microbiota-mediated AMPK and NF-κB activation and SIRT-1 expression (Jang et al. 2019; Uchinaka et al. 2018). This evidence concerns the gene SIRT1 and obesity due to melanocortin 4 receptor deficiency.