CTSS and neoplasm: Tumour astrocyte cell migration is a complex and dynamic process, comprising at least three independent and highly coordinated biological processes [25]: [1] The cell adheres to several components of ECM and modifies ECM molecular composition; [2] the mobility of the cell itself is mainly achieved by modifying the field of integrin and ECM component to reorganise the actin cytoskeleton; [3] cell invasion primarily degrades matrix proteins via proteolytic enzymes secreted by tumours (including serine proteases, cathepsins, and matrix metalloproteinases (MMP)‐2, MMP‐9, and MMP‐14 (MT1‐MMP)).