PROS1 and COVID-19: The damage caused by COVID-19 primarily occurs in the lung tissue but may involve other tissues directly or indirectly, particularly in more critical patients.(8) Myocardial involvement is identified by the presence of high levels of troponin, which has been related to the evolution toward more severe presentations of the disease and death.(9) The proposed mechanism of COVID-19 damage is the excision of the viral S protein by a serine protease, which allows attachment to the angiotensinconverting enzyme 2 (ACE2) and entry into macrophages, perivascular pericytes and cardiomyocytes.