Recently, a loss of virulence has been reported when FAAL-like domain (FLD)-containing protein, CPS1, a DIP2 orthologue, is mutated in either plant pathogenic fungi, which causes rice blast and wheat head scab, or human pathogenic fungus, that cause valley fever (Lu et al., 2003; Narra et al., 2016; Wang et al., 2016). Here, DIP2A is linked to coccidioidomycosis.