A multivariable Cox proportional hazard model, adjusting for age, sex, smoking, hypertension, hypercholesterolemia, diabetes, family history of cardiovascular disease, and previous myocardial infarction, did not affect the association of PV NPY with the combined end point (HR, 1.011 [95% CI, 1.001–1.021]; P=0.03). This evidence concerns the gene NPY and hypertensive disorder.