MTAP was found to have an inhibitory effect on the cell invasion of hepatocellular carcinoma (HCC) (Hellerbrand et al, 2006), and previous studies on proteome and methylproteome alterations triggered by MTAP overexpression further demonstrated vimentin protein downregulation and increased monomethylation on vimentin in HCC cells (Bigaud & Corrales, 2016). The gene discussed is MTAP; the disease is hepatocellular carcinoma.