Cu/Zn-superoxide dismutase (SOD1), TAR DNA-binding protein of 43kDa (TDP-43), fused in sarcoma/ translocated in liposarcoma (FUS/TLS), and vesicle-associated membrane protein-associated protein B (VAPB) are genetic factors in patients with ALS. The gene discussed is TARDBP; the disease is amyotrophic lateral sclerosis.