Published studies from us and others demonstrated that IL-2 alone could exert immunotherapeutics against TB infection and TB lesions [8,33,34], whereas greater expansions of Vγ2Vδ2 T effector cells by more potent Picostim (HMBPP analog) plus IL2 could control primary TB infection better than IL2 alone [7]. The gene discussed is IL2; the disease is tuberculosis.