Among the various subtypes of HTRs expressed by hepatocytes (Li et al., 2018), HTR2A and HTR2B show a strong relationship to liver diseases as they transduce the 5-HT signal from the SI via the portal vein (Lesurtel et al., 2006; Ebrahimkhani et al., 2011; Li et al., 2018; Choi et al., 2018; Lam et al., 2010; Wang et al., 2020). The gene discussed is HTR2A; the disease is liver disorder.