The VOC, 2‐butanone was shown as a potential biomarker (sampled from urine) for hepatocellular carcinoma and is related to a number of processes in the body that are relevant to the malignant process, including inhibition of the membrane‐bound monoamine oxidase activity that is related to metastasis suppress by inhibiting the adrenergic system and its transactivation of epidermal growth factor receptor signaling.[104] In addition, although the p‐value showed significant changes, the values discriminating between healthy and primary tumor stages are not satisfying. The gene discussed is EGFR; the disease is hepatocellular carcinoma.