Based on the results of the correlation analysis of HMGB1 and survival prognosis using GEPIA2, it can be seen that the overexpression of HMGB1 is significantly associated with poor prognosis of the five tumours (ACC, ESCA, KICH, LUAD and PAAD), while the overexpression of HMGB1 is also significantly associated with better prognosis of KIRC and THYM. The gene discussed is HMGB1; the disease is pancreatic adenocarcinoma.