These results demonstrated that the function of HMGB1 in different cancer types is different, such as the correlation of HMGB1 with CAFs is positive in BRCA‐LumA, MESO and TGCT; but is negative in HNSC‐HPV+, which may indicate that the mechanism of HMGB1 is different in different cancer types. The gene discussed is HMGB1; the disease is cancer.