As shown in Figure 1A, the expression levels of HMGB1 in the tumour tissues of CHOL (Cholangiocarcinoma), COAD (Colon adenocarcinoma), ESCA (Oesophageal carcinoma), HNSC (Head and neck squamous cell carcinoma), KICH (Kidney Chromophobe), LIHC (Liver hepatocellular carcinoma), LUAD (Lung adenocarcinoma), LUSC (Lung squamous cell carcinoma), READ (Rectum adenocarcinoma) and STAD (Stomach adenocarcinoma) are significantly different compared with the corresponding normal tissues (p < 0.001). The gene discussed is HMGB1; the disease is rectum adenocarcinoma.