CDKL5 and encephalopathy, progressive, early-onset, with brain edema and/or leukoencephalopathy: Dravet syndrome (DS), Lennox‐Gastaut syndrome (LGS), and CDKL5 deficiency disorder (CDD) are rare, severe, treatment‐resistant developmental and epileptic encephalopathies with distinct etiologies (Camfield, 2011; Gataullina & Dulac, 2017; Olson et al., 2019).