This model is based on the origin of the tumor growth, exhibits local invasion, is associated with steroid hormones, and demonstrates the ability to change the expression of various genes, such as Ras/Raf/mitogen-activated protein kinase (MAPK), P13K/Akt, P53, e-kit, mTOR, and c-myc. The gene discussed is WNK2; the disease is neoplasm.