When we compared three groups of B-cell lymphoma, T-cell lymphoma, and healthy dogs, the serum β2M (p=0.006), clusterin (p=0.01), immunoglobulin (Ig) heavy chain V region GOM (p=0.02), and plasminogen (p=0.02) were significantly higher in B-cell than T-cell lymphoma. This evidence concerns the gene CLU and B-cell non-Hodgkin lymphoma.