Differently higher serum proteins in canine lymphoma were observed in beta-actin cytoplasmic 1 (ACTB, p=0.04), Hp (p=0.002), beta-2 microglobulin (β2M, p=0.007), beta-2 glycoprotein 1 (APOH, p=0.03), metalloproteinase inhibitor 1 (TIMP-1, p=0.03), and CD44 antigen (p=0.02). The gene discussed is HP; the disease is lymphoma.