RUNX1 and cancer: In this article, we summarize new research on the role of RUNX1 mutations, published in February 2020 by three different groups [6-8]. They performed different experiments in human, mouse, and induced pluripotent stem cell (iPSC) models to decipher the role of the RUNX1 gene in the malignant transformation of IBMFS; the mechanisms of pathogenesis; clinical and molecular characteristics of RUNX1 mutations; and the potential for the treatment of cancers.