Among patients without DM, Ratviu et al. examined the long-term effect of rosiglitazone in the Fatty Liver Improvement with Rosiglitazone Therapy (FLIRT) 2 trial and reported that longer therapy does confer no additional benefit upon the regulation of insulin sensitivity and transaminase levels, highlighting that other pathways causing this disease need to be explored and exploited [23]. This evidence concerns the gene INS and diabetes mellitus.