In addition, we found Ad5-Ki67/IL-15 could attenuate PD-L1 expression of mouse glioma cells induced by GA-MSCs in GBM treatment (Fig. 6A, B, P < 0.05, 46.03 ± 6.793 vs. 35.37 ± 0.666). This evidence concerns the gene IL15 and glioblastoma.