Programmed death ligand 1 (PD-L1), which is present in the tumor microenvironment (TME), is an immune inhibitory receptor ligand that leads to immune cell dysfunction and apoptosis by binding to its receptor, programmed death protein 1 (PD-1), which works in braking the inflammatory response and conspiring tumor immune evasion [20, 21]. This evidence concerns the gene CD274 and neoplasm.